Nature has been genetic engineering forever - just research all about Agro-bacterium tumefaciens! Then think about how various organisms came about. In particular, ever wondered why plants have chloroplasts and mitochondria and we have mitochondria? More than that, we do mitochondrial genes in our genome! Cross-breeding and selection are also forms of genetic engineering which occurs by humans and in Nature - that is all trial and error - generally well informed.

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